This Jesuit college was founded in 1858, and had small beginnings at the church of Sant'Andrea della Valle. After being at the Jesuit noviciate at Sant'Andrea al Quirinale, it moved into purpose-built premises in the new district of Prati in 1887. The church was finished in the following year.
The College moved out in 1962, and the complex was subsequently demolished. An apartment block stands on the site.
This was a full-sized church, having a nave and aisles and seven side altars. The interior decoration was sumptious, and a sad loss.
The ceiling vault was frescoed, depicting The Glory of Our Lady and The Dogma of the Immaculate Conception, both by Silverio Capparoni and with stucco work by the firm of Capranesi. The stained glass windows were by Jele of Innsbrück in Austria. Capparoni also executed the Apparition of Our Lady of Guadalupe in the conch of the apse, frescoes in niches in the apse itself and a series of Apostles and Doctors of the Church over the nave arcades..
Bartolini Nella executed The Apparition of Our Lady to St Catherine Labouréin the vault of the presbyterium, The Apparition of Our Lady to St Bernadette over the triumphal arch and John the Baptist, Ezechiel and David on the counterfaçade.
The main altar had chased metalwork by Vincenzo Brugo, and a tabernacle by Paolo Medici. Above was a statue of Our Lady by Giovanni Collina, with bronze work by Etorre Brandizza.
To the right of the main altar was the chapel of Our Lady of Guadalupe, especially finely decorated by Landoni and with marble work by Ricciardi.